Salicinium Therapy
Salicinium demonstrates broad, potent, anti-viral and anti-cancer properties via the following mechanisms:
- Disrupting cancer metabolism/energy production
- Potentiating healthy immune function
- Disrupting the synthesis of the immune-suppressive enzyme nagalase.
Disruption of Cancer Cell Energy Production – Cancer cells are primarily dependent on sugar and fermentation (glycolytic metabolism) for energy to survive. Salicinium directly inhibits cancer cell fermentation (pushing it away from glycolysis to normal cell oxidative phosphorylation) and therefore energy production, leading directly programmed cancer cell death (apoptosis).
GLUT Receptors. All cells have GLUT receptors to transport sugar for energy production. However, because cancer cells are dependent on sugar for energy, they typically over-express GLUT receptors and usually have 5-20 times more GLUT receptors than normal cells. These receptors lead to enhanced uptake of compounds such as salicinium leading to enhanced disruption of cancer cell metabolism.
Disruption of Nagalase Synthesis. Gc protein, which is produced normally, is converted to GcMAF (Gc Macrophage Activating Factor). GcMAF enhances the ability of macrophages (an important immune cell) to both recognize (immune surveillance) and destroy cancer cells.
Nagalase is an enzyme that is produced by cancer cells (and viruses) that inhibits Gc protein from being converted into GcMAF. This results in our immune system being unable to recognize cancer (immune evasion) and therefore unable to destroy cancer cells by one of our most important immune cells. Nagalase also degrades the extracellular matrix of the normal cellular environment enabling cancer cells to invade. Salicinium disrupts nagalase synthesis and thus cancer cells are unable to evade our immune system.
Enhanced Immune Function – Macrophages are important in downstream activation of NK or Natural Killer cells. NK cells are specialized cancer killing and because salicinium prevents nagalase production, it enables macrophages to properly activate NK cells which further destroy cancer cells.
Please note, salicinium does not kill malignant cells directly, it optimizes immune system so that it can do its job.